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   DNA Analysis 

What is DNA Analysis?

It is a test to ascertain your personal gene variants which make you unique. It is conducted by taking a really simple mouth swab test.

Then follows a report specifically taking into account the  unique gene variants you have, a report which is personalised for you. This may be used to assess risk factors for disease, and make appropriate lifestyle changes.

Make sure you are not squeezing the trigger on your ability to perform at your strategic best.

 

This test gives you an opportunity to make a make a huge shift, no less than a change in a paradigm because it is entirely bespoke to you. 

 

DNA testing has opened many doors in enabling us to reset the results of our DNA through epigenetics.

This means that many things that were previously considered genetic it is now clear that they are epigenetic. Epigenetic’s, simply put, is the study of the biological mechanisms that switch genes on and off. Epigenetics is what you eat, where you live, who you interact with, how you exercise, when you sleep, how you age, what toxins you are exposed to and how you handle them. It is the bit that makes us unique. Therefor any change in phenotype does not involve genotype. The best thing is it is possible to reverse epigenetics.i.e turn on or off gene SNPs. A SNP is one single point variation to one nucleotide within a gene. There can be several SNPs in the same gene. Most of them are in non-coding regions. Some of them are in coding regions. We may think of genes as a unit of information or coding instructions. It is not a perfect transmission every time.( see below for further explanation).

 

In terms of optimal performance what could be more effective than a strategy totally unique to your blueprint. An opportunity to tweak your lifestyle in terms of nutrient intake, possible supplements, sleeping at the right time for you, exercising in a way that optimises performance without injury. 

 

I haven't been this excited about advances in nutrition and  medicine since…antibiotics! OK so I wasn't alive then but this is truly the most incredible advance in terms of taking control of your health in my lifetime. 

 

DNA SNPs. These are the variations in our genome which make us unique. 

 

How your genes affect you?

We are all unique - no two people have the same fingerprints and just like fingerprints, no two people have the same genetic variations. It is these variations which are our unique identifiers, from gender to the colour of our eyes, and the types of food that work best with our bodies. They are an instruction manual for creation, repair, and regulation (in terms of timing and location or level). Sometimes the body doesn't copy exactly, one letter may change, this changes the coding of the gene to give a new meaning or function.These are the variations called SNP’s (pronounced snips). Single Nucleotide Polymorphisms……… 

Techie bit 

A bit of revision if you haven't looked at biology since school

DNA Deoxyribonucleic acid

Is shaped like a ladder, and made out of two pieces. It is read in groups of three nucleotides called codons. It is transcribed by a messenger molecule mRNA. The mRNA is read and translated into one amino acid. 

Amino acids are linked together to make proteins. 

DNA’s job is to store information to make proteins.

Deoxyribose is the side rails, and the nucleotides are the rungs (or bases).

The bases are A,C,G and T. Adenine, cytosine, guanine and thymine.

DNA and RNA live mainly in the nucleus (Mitochondrial DNA doesn’t).

Before it can be used to code it needs mRNA to get out of the nucleus.

What causes DNA mutations or variations ?

Variants, SNPs and mutations arise spontaneously due to errors in replication. Natural exposure of an organism to certain environmental factors such as ultraviolet light and chemical carcinogens can also cause mutations.

Some mutations variations happened to give us an evolutionary advantage e.g the ability to store energy when food was scarce. This may not be an advantage when food is freely available, in large quantities and very easy to get- i.e.take aways!

We have an inbuilt quality assurance process which checks for damage at various checkpoints. It can repair damage in several ways, and is really very good at it. Although not perfect, and this can be influenced by your environment.

 

When you know your SNP variations it is possible to really personalise supplementation and lifestyle interventions for the best possible outcomes of genetic potential.

 

Let me be clear, as with most preferences, health risks, and genetic traits, there are many complex, interrelated factors.

There is almost never one single gene that inevitably leads to a given result.

Any genetic data we share are simply clues for further exploration.

 

We can help optimise wellness by testing you nutrigenomics. Nutrigenomics is the study of how genes and nutrients interact. 

Knowing your nutrigenomics explains how common variations in the human genome explain individual differences in response to dietary intake and much more. This is great news! It means that we now have more power to eat a specific personalised diet unique for your genetic blueprint including lifestyle, diet, exercise and supplementation. The report will help you understand how your genes affect the choices you make and their consequences.

 

Some individuals respond differently to ingesting  exactly the  same nutrients. It also explains why some people can eat and thrive on a high fat diet and others just look at a fry up and put on weight, have increased cholesterol and high triglycerides.

 

Certain genes/SNPs affect the rate of absorption, distribution, metabolism and excretion of almost everything we eat. For example the gene which can be activated by compounds found in broccoli is missing in about 20% of the population. So some people won’t benefit from the detoxifying properties in broccoli (although they will still benefit from the antioxidants). 

 

Genetic information can tell us how we might change (if we wanted to), and what the payoff from that change might be.

 

Lets take caffeine for example. Studies in JAMA,  Journal of American Medical Association have shown in some individuals caffeinated coffee intake lowered the risk of heart attacks and some it increased the risk of heart attacks. It is dependent on whether you have the “slow” or fast version of the CYP1A2 (the gene for breaking down caffeine in the liver). The fast version have a lower risk of heart attack with moderate intakes of caffeinated coffee at a dose of 1 to 3 cups a day. The findings suggest that those who have a limited capacity to break down caffeine have an increased risk of heart disease. 

Whereas those with the fast version are getting rid of the caffeine whilst preserving the healthy antioxidants in the coffee.  The clearance of caffeine  can vary up to 40 fold within and between individuals. So some people may now be identifying with the slow metaboliser type, saying “That’s me, I can’t drink coffee in the afternoon because it keeps me up all night”. But actually this just means the caffeine binds more effectively to a specific receptor in the nervous system, which determines how caffeine acts as a stimulant.The only way to know if you are a fast or slow metaboliser is to have the test done. Mutations and alterations to our genetic code happen all the time.

Sometimes they matter. Sometimes not.

 

As medicine advances and is more able to treat patients using personalised care and targeted therapies, better outcomes can be expected. Our health is a complex web of interactions, our genome and lifestyle choices. I am happy to talk this through with you.

Email me for a free 15 minute skype or phone call.

WHAT PEOPLE SAY

Susie has a vast breadth of knowledge that she uses to great effect to unravel why a person is physically and mentally functioning as they are and how they can reach an optimum state. Her retreats are fun, informative, the food is lovely and Ibiza was a wonderful setting. The restorative yoga at the end of the day was incredibly relaxing and I loved it."

—  Helen Davies, Bucks.

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